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Emerin 抗体 (AA 1-48)

Name: Emerin 抗体 (AA 1-48)
SKU: ABIN5647115
Availability: OutOfStock

EMD 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Western blot testing of 1) rat skeletal muscle, 2) mouse heart and 3) human HeLa lysate with Emerin antibody at 0. (Emerin 抗体 (AA 1-48))

IHC testing of FFPE human lung cancer tissue with Emerin antibody at 1ug/ml. (Emerin 抗体 (AA 1-48))

IHC

2 images

产品编号 ABIN5647115

发货至: 中国

Datasheet as PDF

抗原 See all Emerin (EMD) 抗体

Emerin (EMD)
抗原表位
15

8

8

4

3

3

2

2

1

1

1

1

1

1

1
AA 1-48
适用
59

15

12

3

2

1

1

1

1

1
人, 小鼠, 大鼠
宿主
47

12

2
兔
Compatible Secondaries
克隆类型
47

14
多克隆
标记
35

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Emerin antibody is un-conjugated
应用范围
47

16

14

13

13

10

8

8

6

5

4

2

2

2

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

Antigen affinity purified

免疫原

Amino acids 1-48 (MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL-human) were used as the immunogen for the Emerin antibody.

亚型

IgG

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EMD 适用: 人, 兔 WB, IF, ICC 宿主: 小鼠 Monoclonal MANEM1(5D10) unconjugated

应用备注

Optimal dilution of the Emerin antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL

限制

仅限研究用
缓冲液

0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

储存条件

-20 °C

储存方法

After reconstitution, the Emerin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
抗原

Emerin (EMD)

别名

Emerin (EMD 产品)

背景

Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene. And this gene is mapped to Xq28. Emerin is a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Emery-Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene. Emerin appears to be involved in mechanotransduction, as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli. In cardiac muscle, emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs, and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta.

UniProt

P50402