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Separase 抗体 (AA 586-701)

Name: Separase 抗体 (AA 586-701)
SKU: ABIN564183
Availability: OutOfStock

ESPL1 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 6H6 unconjugated

Western Blot detection against Immunogen (38. (Separase 抗体 (AA 586-701))

Immunoperoxidase of monoclonal antibody to ESPL1 on formalin-fixed paraffin-embedded human prostate. (Separase 抗体 (AA 586-701))

ISt

ESPL1 monoclonal antibody (M01), clone 6H6 Western Blot analysis of ESPL1 expression in Hela S3 NE . (Separase 抗体 (AA 586-701))

3 images

(7 references)

产品编号 ABIN564183

发货至: 中国

Datasheet as PDF

抗原 See all Separase (ESPL1) 抗体

Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
抗原表位
17

15

15

9

6

6

6

5

2

2

2

2

1

1

1

1

1
AA 586-701
适用
93

10

1
人
宿主
89

4

1
小鼠
Compatible Secondaries
克隆类型
90

4
单克隆
标记
30

9

9

8

5

5

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This Separase antibody is un-conjugated
应用范围
47

39

26

26

20

13

11

7

6

2

1

1

1
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Mouse monoclonal antibody raised against a partial recombinant ESPL1.

序列

REELQAYKAV RADTGQERFN IICDLLELSP EETPAGAWAR ATHLVELAQV LCYHDFTQQT NCSALDAIRE ALQLLDSVRP EAQARDQLLD DKAQALLWLY ICTLEAKIQE GIERDR

交叉反应

人

产品特性

Antibody Reactive Against Recombinant Protein.

免疫原

ESPL1 (NP_036423, 586 a.a. ~ 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

克隆位点

6H6

亚型

IgG2a
anti-Extra Spindle Poles Like 1 (ESPL1) antibody
ESPL1 适用: 人, 小鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (Tyr489) antibody
ESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (pSer1126) antibody
ESPL1 适用: 人 IHC (p), DB 宿主: 兔 Polyclonal RB7943 unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (AA 767-816) antibody
ESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibody
ESPL1 适用: 人 IHC, WB, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibody
ESPL1 适用: 人 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (AA 1292-1495) antibody
ESPL1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) antibody
ESPL1 适用: 小鼠 WB 宿主: 山羊 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (pSer1126) antibody
ESPL1 适用: 人 IF 宿主: 兔 Polyclonal unconjugated

anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibody
ESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
缓冲液

In 1x PBS, pH 7.4

注意事项

Aliquot to avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Mukherjee, Ge, Zhang, Edwards, Sumazin, Sharan, Rao, Medina, Pati: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).

Mukherjee, Byrd, Brawley, Bielamowicz, Li, Merchant, Maitra, Sumazin, Fuller, Kew, Sun, Powell, Ahmed, Zhang, Pati: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).

Zhang, Scorsone, Ge, Kaffes, Dobrolecki, Mukherjee, Lewis, Berg, Stephan, Pati: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).

Mukherjee, Ge, Zhang, Huang, Nakamura, Minor, Fofanov, Rao, Herron, Pati: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).

Panigrahi, Zhang, Mao, Pati: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).

Meyer, Fofanov, Panigrahi, Merchant, Zhang, Pati: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).

Zhang, Ge, Meyer, Sethi, Basu, Pradhan, Zhao, Li, Cai, El-Naggar, Baladandayuthapani, Kittrell, Rao, Medina, Pati: "Overexpression of Separase induces aneuploidy and mammary tumorigenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 13033-8, (2008) (PubMed).
抗原

Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

别名

ESPL1 (ESPL1 产品)

别名

ESP1 antibody, SEPA antibody, mp:zf637-3-001691 antibody, AL024103 antibody, AU045071 antibody, Cerp antibody, PRCE antibody, SSE antibody, extra spindle pole bodies like 1, separase antibody, extra spindle poles like 1 antibody, extra spindle pole bodies 1, separase antibody, ESPL1 antibody, espl1 antibody, Espl1 antibody

背景

Full Gene Name: extra spindle pole bodies homolog 1 (S. cerevisiae)
Synonyms: ESP1,FLJ46492,KIAA0165,SEPARASE,SEPARIN

基因ID

9700

NCBI登录号

NM_012291