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SIRPA 抗体 (AA 235-373)

Name: SIRPA 抗体 (AA 235-373)
Brand: antibodies-online
SKU: ABIN5611267
Availability: OutOfStock

SIRPA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2H7E2 unconjugated

Western blot analysis using CD172A mAb against human CD172A (AA: extra 235-373) recombinant protein. (SIRPA 抗体 (AA 235-373))

Black line: Control Antigen (100 ng),Purple line: Antigen (10 ng), Blue line: Antigen (50 ng), Red line:Antigen (100 ng) (SIRPA 抗体 (AA 235-373))

ELISA

Flow cytometric analysis of Ramos cells using CD172A mouse mAb (green) and negative control (red). (SIRPA 抗体 (AA 235-373))

FACS

Western blot analysis using CD172A mAb against HEK293 (1) and CD172A (AA: extra 235-373)-hIgGFc transfected HEK293 (2) cell lysate. (SIRPA 抗体 (AA 235-373))

4 images

(1 reference)

产品编号 ABIN5611267

发货至: 中国

Datasheet as PDF

抗原 See all SIRPA 抗体

SIRPA (Signal-Regulatory Protein alpha (SIRPA))
抗原表位
16

14

5

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 235-373
适用
69

39

32

9

8

3

3

3
人
宿主
58

30

1

1
小鼠
Compatible Secondaries
克隆类型
57

33
单克隆
标记
45

10

7

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This SIRPA antibody is un-conjugated
应用范围
56

43

19

17

13

12

11

9

9

2

1

1
Flow Cytometry (FACS), ELISA

原理

CD172A Antibody

纯化方法

Purified antibody

免疫原

Purified recombinant fragment of human CD172A (AA: 235-373) expressed in E. Coli.

克隆位点

2H7E2

亚型

IgG1

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应用备注

ELISA: 1/10000
FCM: 1/200 - 1/400

限制

仅限研究用
状态

Liquid

缓冲液

Purified antibody in PBS with 0.05 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Deuse, Hu, Agbor-Enoh, Jang, Alawi, Saygi, Gravina, Tediashvili, Nguyen, Liu, Valantine, Lanier, Schrepfer: "The SIRPα-CD47 immune checkpoint in NK cells." in: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).
抗原

SIRPA (Signal-Regulatory Protein alpha (SIRPA))

别名

CD172A (SIRPA 产品)

别名

BIT antibody, CD172A antibody, MFR antibody, MYD-1 antibody, P84 antibody, PTPNS1 antibody, SHPS1 antibody, SIRP antibody, SIRPA antibody, SIRP-A1 antibody, SIRP-B1 antibody, AI835480 antibody, Bit antibody, CD172a antibody, Ptpns1 antibody, SHP-1 antibody, SHPS-1 antibody, swc3 antibody, signal regulatory protein alpha antibody, myeloperoxidase antibody, signal-regulatory protein alpha antibody, tyrosine-protein phosphatase non-receptor type substrate 1 antibody, SIRPA antibody, MPO antibody, LOC458039 antibody, LOC100400378 antibody, LOC100590224 antibody, Sirpa antibody

背景

Description: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Aliases: BIT, MFR, P84, SIRP, MYD-1, SHPS1, SIRPA, PTPNS1

分子量

55kDa

基因ID

140885

HGNC

140885

UniProt

P78324