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MME 抗体 (AA 549-750)

MME 适用: 人 FACS, WB, IHC, ELISA, ICC, Neut 宿主: 小鼠 Monoclonal 6G12E12 unconjugated
产品编号 ABIN5611260
发货至: 中国
  • 抗原 See all MME 抗体
    MME (Membrane Metallo-Endopeptidase (MME))
    抗原表位
    • 14
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    AA 549-750
    适用
    • 190
    • 44
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    • 3
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    宿主
    • 99
    • 96
    • 2
    小鼠
    克隆类型
    • 105
    • 91
    • 2
    单克隆
    标记
    • 105
    • 20
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    This MME antibody is un-conjugated
    应用范围
    • 111
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    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Neutralization (Neut)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human CD10 (AA: extra 549-750) expressed in E. coli.
    克隆位点
    6G12E12
    亚型
    IgG1
    Top Product
    Discover our top product MME Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • 抗原
    MME (Membrane Metallo-Endopeptidase (MME))
    别名
    CD10 (MME 产品)
    别名
    CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody
    物质类
    Chemical
    背景

    Description: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

    Aliases: NEP, SFE, MME, CALLA, CMT2T, SCA43

    分子量
    85.5 kDa
    基因ID
    4311
    HGNC
    4311
    途径
    RTK signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
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