GRM8 抗体 (AA 440-583)
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- 抗原 See all GRM8 抗体
- GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
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抗原表位
- AA 440-583
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GRM8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- 原理
- GRM8 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human GRM8 (AA: 440-583) expressed in E. Coli.
- 克隆位点
- 4C1C1
- 亚型
- IgG1
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
- 别名
- GRM8 (GRM8 产品)
- 别名
- mGluR8 antibody, GRM8 antibody, MGLUR8 antibody, GLUR8 antibody, GPRC1H antibody, mGlu8 antibody, A230002O04 antibody, Gprc1h antibody, Glur8 antibody, Mglur8 antibody, mGluR8b antibody, mGlur antibody, glutamate metabotropic receptor 8 antibody, metabotropic glutamate receptor 8 antibody, glutamate receptor, metabotropic 8 antibody, GRM8 antibody, MGLUR8 antibody, LOAG_14062 antibody, Grm8 antibody
- 背景
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Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Aliases: GLUR8, mGlu8, GPRC1H, MGLUR8
- 分子量
- 101.7kDa
- 基因ID
- 2918
- HGNC
- 2918
- UniProt
- O00222
- 途径
- cAMP Metabolic Process, Synaptic Membrane
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