我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

GCH1 抗体 (AA 84-172)

Name: GCH1 抗体 (AA 84-172)
SKU: ABIN561018
Availability: OutOfStock

GCH1 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 4A12 unconjugated

GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 . (GCH1 抗体 (AA 84-172))

Immunoperoxidase of monoclonal antibody to GCH1 on formalin-fixed paraffin-embedded human lymph node. (GCH1 抗体 (AA 84-172))

ISt

Detection limit for recombinant GST tagged GCH1 is approximately 0. (GCH1 抗体 (AA 84-172))

ELISA

Immunoprecipitation of GCH1 transfected lysate using anti-GCH1 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with GCH1 MaxPab rabbit polyclonal antibody. (GCH1 抗体 (AA 84-172))

Western Blot analysis of GCH1 expression in transfected 293T cell line by GCH1 monoclonal antibody (M01), clone 4A12. (GCH1 抗体 (AA 84-172))

Western Blot detection against Immunogen (35. (GCH1 抗体 (AA 84-172))

6 images

(11 references)

产品编号 ABIN561018

发货至: 中国

Datasheet as PDF

抗原 See all GCH1 抗体

GCH1 (GTP Cyclohydrolase 1 (GCH1))
抗原表位
15

11

8

6

6

6

2

2

1

1

1
AA 84-172
适用
40

24

10

4

4

4

2

2

2

1

1

1

1

1

1

1
人
宿主
49

6

1
小鼠
Compatible Secondaries
克隆类型
54

2
单克隆
标记
22

5

5

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This GCH1 antibody is un-conjugated
应用范围
47

28

18

13

13

5

5

3

3
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

原理

Mouse monoclonal antibody raised against a partial recombinant GCH1.

序列

ENPQRQGLLK TPWRAASAMQ FFTKGYQETI SDVLNDAIFD EDHDEMVIVK DIDMFSMCEH HLVPFVGKVH IGYLPNKQVL GLSKLARIV

交叉反应

人

产品特性

Antibody Reactive Against Recombinant Protein.

免疫原

GCH1 (NP_000152, 84 a.a. ~ 172 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

克隆位点

4A12

亚型

IgG2a
anti-GTP Cyclohydrolase 1 (GCH1) (AA 1-250) antibody
GCH1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (Internal Region) antibody
Verified GCH1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) antibody
GCH1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (AA 1-250) antibody
GCH1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (AA 1-250) antibody
GCH1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1F5 unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (AA 1-250) antibody
GCH1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2C4 unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (AA 34-110) antibody
GCH1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (AA 1-250) antibody
GCH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (AA 84-172) antibody
GCH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-GTP Cyclohydrolase 1 (GCH1) (C-Term) antibody
GCH1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, Pig, 豚鼠, Bat, 小鸡, 猴, 非洲爪蟾, Hamster WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
缓冲液

In 1x PBS, pH 7.4

注意事项

Aliquot to avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).

Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

Pickert, Lim, Weigert, Häussler, Myrczek, Waldner, Labocha, Ferreirós, Geisslinger, Lötsch, Becker, Brüne, Tegeder: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).

Oelze, Knorr, Schuhmacher, Heeren, Otto, Schulz, Reifenberg, Wenzel, Münzel, Daiber: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).

Teng, Du, Xu, Bakhutashvili, Eis, Shi, Pritchard, Konduri: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).

Schuhmacher, Oelze, Bollmann, Kleinert, Otto, Heeren, Steven, Hausding, Knorr, Pautz, Reifenberg, Schulz, Gori, Wenzel, Münzel, Daiber: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).

Kröller-Schön, Schulz, Wenzel, Kleschyov, Hortmann, Torzewski, Oelze, Renné, Daiber, Münzel: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).

Wenzel, Daiber, Oelze, Brandt, Closs, Xu, Thum, Bauersachs, Ertl, Zou, Förstermann, Münzel: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).

Seujange, Eiam-Ong, Tirawatnapong, Eiam-Ong: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).

Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: "Regulation of tetrahydrobiopterin biosynthesis by shear stress." in: Circulation research, Vol. 101, Issue 8, pp. 830-8, (2007) (PubMed).
抗原

GCH1 (GTP Cyclohydrolase 1 (GCH1))

别名

GCH1 (GCH1 产品)

别名

DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH antibody, GTP-CH-1 antibody, GTPCH1 antibody, HPABH4B antibody, GTP-CH antibody, GTPCH antibody, Gch antibody, MGC89622 antibody, gch1a antibody, wu:fc16b10 antibody, zgc:195269 antibody, GTP cyclohydrolase 1 antibody, GTP cyclohydrolase 1-like antibody, GCH1 antibody, Gch1 antibody, gch1 antibody, Weevi_1190 antibody, Halhy_0838 antibody, Sinme_1220 antibody, Sphch_1077 antibody, LOC100136794 antibody

背景

Full Gene Name: GTP cyclohydrolase 1
Synonyms: DYT14,DYT5,GCH,GTP-CH-1,GTPCH1

基因ID

2643

NCBI登录号

NM_000161