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TET2 抗体 (N-Term)

TET2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5596979
发货至: 中国
  • 抗原 See all TET2 抗体
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    抗原表位
    • 16
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    适用
    • 47
    • 15
    • 6
    宿主
    • 41
    • 8
    • 2
    克隆类型
    • 43
    • 8
    多克隆
    标记
    • 33
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TET2 antibody is un-conjugated
    应用范围
    • 38
    • 22
    • 11
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    交叉反应 (详细)
    It is directed against, and shows specific reactivity for human Tet2 protein. Cross reactivity with Tet1 and Tet3 has not been determined.
    纯化方法
    Anti-TET2 Antibody was prepared from whole rabbit antiserum by delipidation and defibrination. The antiserum was further cross-absorbed against MBP by chromatography.
    免疫原

    Immunogen: TET2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a human TET-2 domain containing the N-terminal 156 amino acids of the protein.

    Immunogen Type: Recombinant Protein

    Top Product
    Discover our top product TET2 Primary Antibody
  • 应用备注

    Application Note: Tet2 antibody has been tested for use by ELISA and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect band at ~230 kDa and ~150 kDa (isoforms).

    Western Blot Dilution: 1:5000

    ELISA Dilution: 1:50,000

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    72.50 mg/mL
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    有效期
    12 months
  • 抗原
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    别名
    TET2 (TET2 产品)
    别名
    KIAA1546 antibody, MDS antibody, Ayu17-449 antibody, E130014J05Rik antibody, mKIAA1546 antibody, RGD1311625 antibody, tet methylcytosine dioxygenase 2 antibody, TET2 antibody, Tet2 antibody
    背景

    Synonyms: Tet2 antibody, Methylcytosine dioxygenase TET2, KIAA1546 antibody, myeloproliferative disorder antibody, MPD antibody, hematopoietic cell antibody, TET2 antibody,Tet oncogene 2 antibody, MDS antibody, TET2_HUMAN antibody

    Background: Tet2 antibody is a dioxygenase enzyme which is associated with the addition of the hydroxyl group to 5-methylcystosine (5mC) to form 5-hydroxymethylcystosine. Tet2 mediates the formation of 5-formylcystosine from 5hmC and subsequently 5fC to 5-carboxylcystosine, and consequently Tet2 plays an active role in catalyzing those conversions which have been suggested as the first step for active mammalian DNA de-methylation. Tet2 enzyme aids in the epigenetic modification of mammalian cystosine bases, ultimately affecting transcriptional regulation. Additionally methylcystosine dioxygenase Tet2 recruits O-GlcNAc transferase OGT enzyme to CpG-rich transcription start sites of the gene, encouraging H2B GlcNAcylation by OGT. Anti-TET2 antibodies are ideal for researchers interested in Epigenetics, Cancer, Chromatin Research and Histone research.

    Gene Name: TET2

    基因ID
    54790
    UniProt
    Q6N021
    途径
    Warburg Effect
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