我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

APP 抗体 (C-Term)

Name: APP 抗体 (C-Term)
SKU: ABIN5596698
Availability: OutOfStock

APP 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

ELISA

1 image

产品编号 ABIN5596698

发货至: 中国

Datasheet as PDF

抗原 See all APP 抗体

APP (Amyloid beta (A4) Precursor Protein (APP))
抗原表位
30

27

24

20

17

17

11

8

8

8

7

6

6

5

4

4

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
233

112

106

12

10

9

9

9

9

8

7

5

4

4

3

1

1

1

1

1
人, 小鼠
宿主
195

73

4

4

2
兔
Compatible Secondaries
克隆类型
215

63
多克隆
标记
144

24

19

18

7

6

4

4

4

4

4

4

4

4

4

4

4

2

2

2

2

2

2

2

2

1
This APP antibody is un-conjugated
应用范围
179

130

77

52

52

44

39

29

27

15

14

6

5

3

2

2

1

1

1

1
Western Blotting (WB), ELISA

原理

Beta Amyloid 42 Antibody

交叉反应（详细）

A BLAST analysis was used to suggest reactivity with human, sheep, rabbit, canine, bovine, pig, guinea pig, and monkey based on 100 % sequence homology.

产品特性

Synonyms: rabbit anti-Beta Amyloid 42 Antibody, ß-amyloid 42, Amyloid beta A4 protein, Alzheimer disease amyloid protein, Beta amyloid, A-beta, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Protease nexin-II

纯化方法

Anti-Beta Amyloid 42 was affinity purified from monospecific antiserum by immunoaffinity chromatography.

过滤

Sterile filtered

免疫原

Immunogen: Anti-Beta Amyloid 42 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of AB42.
Immunogen Type: Conjugated Peptide

亚型

IgG

Top Product

Discover our top product APP Primary Antibody
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人 WB, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
APP 适用: 人, 小鼠 WB, ELISA, IHC, IF, FM 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 190-290) antibody
APP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) antibody
APP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-270) antibody
APP 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
KO Validated APP 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 381-480) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

应用备注

Application Note: Anti-Beta Amyloid 1-42 antibody has been tested by ELISA and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~86 kDa corresponding to the appropriate cell lysate or extract.
Western Blot Dilution: 1 μg/mL
ELISA Dilution: 1: 10,000

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

有效期

12 months
抗原

APP (Amyloid beta (A4) Precursor Protein (APP))

别名

APP (APP 产品)

背景

Background: Beta Amyloid functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It is expressed in all fetal tissues with the highest levels located in the brain, kidney, heart and spleen tissue. It is involved in cell mobility, transcription regulation via protein-protein interactions and copper homeostasis/oxidative stress through copper ion reduction. The copper-metallated APP induces neuronal death directly in vitro, or is potentiated through Cu2+ mediated low-density lipoprotein oxidation. It has binding capabilities via its C-terminus for transient metals such as copper, zinc and iron. It binds APBB1-KAT5 to promote transcription activation and inhibits Notch signaling through interaction with Numb. It also promotes tau aggregation and TPK II-mediated phosphorylation. Anti-Beta Amyloid 42 regulates neurite outgrowth by binding components in the cellular matrix such as heparin, collagen I and amyloid-beta peptide, leading to mitochondrial dysfunction in cultured cortical neurons. Defects in APP cause Alzheimer disease type 1 and cerebral amyloid angiopathy. This antibody is ideal for researchers interested in Cancer or Neuroscience research.

NCBI登录号

NP_000475

UniProt

P05067

途径

Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour