Recombinant CD40L (Ruplizumab Biosimilar) 抗体
-
- 抗原 See all CD40L (Ruplizumab Biosimilar) products
- CD40L (Ruplizumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人, 犬
-
宿主
-
Human
-
克隆类型
- 单克隆
-
标记
- This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)
- 特异性
- Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.
- 交叉反应
- 犬, 人
- 交叉反应 (详细)
- Cross-reacts with canine CD40L.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.001EU/μg
- 免疫原
- Recombinant human CD40L.
- 克隆位点
- Hu5c8
- 亚型
- IgG1
-
-
- 说明
-
This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS.
- 储存液
- Without preservative
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C. - 有效期
- 12 months
-
- 抗原
- CD40L (Ruplizumab Biosimilar)
- Abstract
- CD40L (Ruplizumab Biosimilar) 产品
- 别名
- CD154 antibody, CD40L antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TNFSF5 antibody, TRAP antibody, gp39 antibody, hCD40L antibody, CD40 ligand antibody, CD40LG antibody
- 物质类
- Biosimilar
- 背景
- CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
- UniProt
- P29965
-