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Recombinant CD40L (Ruplizumab Biosimilar) 抗体

适用: 人, 犬 FACS, WB, Func 宿主: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
产品编号 ABIN5564228
发货至: 中国
  • 抗原 See all CD40L (Ruplizumab Biosimilar) products
    CD40L (Ruplizumab Biosimilar)
    抗体类型
    Recombinant Antibody
    适用
    人, 犬
    宿主
    • 1
    • 1
    • 1
    Human
    克隆类型
    • 3
    单克隆
    标记
    • 3
    This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated
    应用范围
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)
    特异性
    Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.
    交叉反应
    犬, 人
    交叉反应 (详细)
    Cross-reacts with canine CD40L.
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.001EU/μg
    免疫原
    Recombinant human CD40L.
    克隆位点
    Hu5c8
    亚型
    IgG1
  • 说明

    This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    In PBS.
    储存液
    Without preservative
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.
    有效期
    12 months
  • 抗原
    CD40L (Ruplizumab Biosimilar)
    Abstract
    CD40L (Ruplizumab Biosimilar) 产品
    别名
    CD154 antibody, CD40L antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TNFSF5 antibody, TRAP antibody, gp39 antibody, hCD40L antibody, CD40 ligand antibody, CD40LG antibody
    物质类
    Biosimilar
    背景
    CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
    UniProt
    P29965
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