Recombinant CD40L (Ruplizumab Biosimilar) 抗体
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- 抗原 See all CD40L (Ruplizumab Biosimilar) products
- CD40L (Ruplizumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人, 犬
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宿主
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Human
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克隆类型
- 单克隆
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标记
- This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)
- 特异性
- Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.
- 交叉反应
- 犬, 人
- 交叉反应 （详细）
- Cross-reacts with canine CD40L.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.001EU/μg
- 免疫原
- Recombinant human CD40L.
- 克隆位点
- Hu5c8
- 亚型
- IgG1
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anti-CD40L (Ruplizumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-CD40L (Ruplizumab Biosimilar) antibody适用: 人 FACS, WB, BR 宿主: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
anti-CD40L (Ruplizumab Biosimilar) antibody适用: 人 FACS, WB, BR 宿主: 兔 Monoclonal hu5c8 unconjugated Recombinant Antibody
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- 说明
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This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS.
- 储存液
- Without preservative
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C. - 有效期
- 12 months
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- 抗原
- CD40L (Ruplizumab Biosimilar)
- Abstract
- CD40L (Ruplizumab Biosimilar) 产品
- 物质类
- Biosimilar
- 背景
- CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
- UniProt
- P29965
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