SMAD4 抗体
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- 抗原 See all SMAD4 抗体
- SMAD4 (SMAD Family Member 4 (SMAD4))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This SMAD4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant human Smad4 protein, around N-terminal 1-200aa.
- 克隆位点
- 3A1
- 亚型
- IgG
- Top Product
- Discover our top product SMAD4 Primary Antibody
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anti-SMAD Family Member 4 (SMAD4) (N-Term) antibody
SMAD4 适用: 人 WB, IP, CUT&RUN 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 1-552) antibodySMAD4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodyKO Validated SMAD4 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodySMAD4 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4G1C6 unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 400-428) antibodySMAD4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 27-195) antibodySMAD4 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 255-284) antibodySMAD4 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB14714 unconjugated
anti-SMAD Family Member 4 (SMAD4) (pThr277) antibodySMAD4 适用: 人 ELISA, IHC, IF, DB 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 9-231) antibodySMAD4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 56-165) antibodySMAD4 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3D7 unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SMAD4 (SMAD Family Member 4 (SMAD4))
- 别名
- Smad4 (SMAD4 产品)
- 背景
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Synonyms: JIP, DPC4, MADH4, MYHRS, Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4, SMAD 4, Smad4, hSMAD4
Background: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- 基因ID
- 4089
- UniProt
- Q13485
- 途径
- Cell Division Cycle, Chromatin Binding, Autophagy
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