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c-MYC 抗体 (pSer62)

Name: c-MYC 抗体 (pSer62)
SKU: ABIN5557289
Availability: OutOfStock

MYC 适用: 人, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 1A7 unconjugated

Lane 1: A549, Lane 2: HCT116, Lane 3: Hela, Lane 4: HepG2 cell lysates, probed with c-Myc(S62) (1A7 ) Monoclonal Antibody at 1:1000 overnight at 4˚C. (c-MYC 抗体 (pSer62))

HeLa cells were stained with c-Myc(S62) (1A7 ) Monoclonal Antibody (b at [1:200] incubated overnight at 4C, followed by secondary antibody incubation, DAPI staining of the nuclei and detection. (c-MYC 抗体 (pSer62))

IF (cc)

2 images

产品编号 ABIN5557289

发货至: 中国

Datasheet as PDF

抗原 See all c-MYC (MYC) 抗体

c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
抗原表位
58

49

46

40

24

22

17

15

15

14

10

7

7

6

6

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer62
适用
360

165

117

16

15

13

13

13

10

10

8

7

7

6

5

4

3

3

2

2

2

1

1

1

1

1

1
人, 大鼠
宿主
279

98

7

5

3

1
兔
Compatible Secondaries
克隆类型
274

118
单克隆
标记
191

31

24

23

8

8

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

3

2

2

2

2

2

2

2

1

1

1

1

1

1
This c-MYC antibody is un-conjugated
应用范围
287

139

97

80

77

57

56

27

26

21

16

14

12

11

7

4

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

交叉反应

人, 大鼠

纯化方法

Purified by Protein A.

免疫原

Synthetic peptide derived from human c-Myc(S62), around 50-100aa (phospho S62).

克隆位点

1A7

亚型

IgG

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anti-Myc Proto-Oncogene protein (MYC) (N-Term) antibody
MYC 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Myc Proto-Oncogene protein (MYC) antibody
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anti-Myc Proto-Oncogene protein (MYC) (pThr358) antibody
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应用备注

WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

别名

c-Myc (MYC 产品)

背景

Synonyms: Avian myelocytomatosis viral oncogene homolog, bHLHe39, c Myc, c Myc Epitope Tag, c Myc Tag, Cellular myelocytomatosis oncogene, MGC105490, MRTL, Myc Epitope Tag, Myc protein, Myc proto oncogene protein, Myc proto-oncogene protein, Myc-related translation/localization regulatory factor, Myc2, myca, Myelocytomatosis oncogene a, Myelocytomatosis oncogene, Niard, Nird, Oncogene Myc, Protooncogene homologous to myelocytomatosis virus, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, V-Myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog avian, zc-myc.
Background: Epitope tags are useful for the labeling and detection of proteins usingimmunoblotting, immunoprecipitation and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria, yeast,insect and mammalian cell systems.The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

基因ID

4609

UniProt

P01106

途径

p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect