c-MET 抗体 (AA 743-932)
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- 抗原 See all c-MET (MET) 抗体
- c-MET (MET) (Met Proto-Oncogene (MET))
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抗原表位
- AA 743-932
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This c-MET antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- 原理
- MET Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human MET (AA: 743-932) expressed in E. Coli.
- 克隆位点
- 5E9B7
- 亚型
- IgG2a
- Top Product
- Discover our top product MET Primary Antibody
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/100 - 1/500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- c-MET (MET) (Met Proto-Oncogene (MET))
- 别名
- MET (MET 产品)
- 别名
- AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody
- 背景
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Description: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
Aliases: HGFR, AUTS9, RCCP2, c-Met, DFNB97
- 分子量
- 155kDa
- 基因ID
- 4233
- HGNC
- 1153
- UniProt
- P08581
- 途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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