MAP2K3 抗体 (AA 1-138)
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- 抗原 See all MAP2K3 抗体
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
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抗原表位
- AA 1-138
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MAP2K3 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
- 原理
- MAP2K3 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human MAP2K3 (AA: 1-138) expressed in E. Coli.
- 克隆位点
- 2E12D11
- 亚型
- IgG1
- Top Product
- Discover our top product MAP2K3 Primary Antibody
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- 别名
- MAP2K3 (MAP2K3 产品)
- 别名
- MAPKK3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, SAPKK-2 antibody, SAPKK2 antibody, AW212142 antibody, Prkmk3 antibody, mMKK3b antibody, Mkk3 antibody, mitogen-activated protein kinase kinase 3 antibody, mitogen activated protein kinase kinase 3 antibody, MAP kinase activator XMEK3 antibody, MAP2K3 antibody, Map2k3 antibody, map2k3 antibody
- 背景
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Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Aliases: MEK3, MKK3, MAPKK3, PRKMK3, SAPKK2, SAPKK-2
- 分子量
- 39.3kDa
- 基因ID
- 5606
- HGNC
- 5606
- UniProt
- P46734
- 途径
- MAPK Pathway, TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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