CEACAM5/6 抗体
CEACAM5/6
适用: 人
FACS, IHC (fro), WB, EIA, ICC, IF
宿主: 小鼠
Monoclonal
MUS
unconjugated
(2 references)-
- 抗原 See all CEACAM5/6 products
- CEACAM5/6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5/6 (CEACAM5/6))
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CEACAM5/6 antibody is un-conjugated
- 应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Enzyme Immunoassay (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- This antibody reacts to CD66c/e. Species: Human.
- 纯化方法
- Affinity Chromatography on Protein G
- 免疫原
- MUS was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors (3).
- 克隆位点
- MUS
- 亚型
- IgG1
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anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5/6 (CEACAM5/6) antibody
CEACAM5/6 适用: 人 FACS, IHC (fro), WB, cELISA, ELISA 宿主: 小鼠 Monoclonal MUS unconjugated
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- 应用备注
- Flow Cytometry: 1.2 μg/10 6 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200. Western blot: 4 μg/mL. Immunohistochemistry: 1-2 μg/10 cells (on Cryosections).
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Phosphate buffered saline, pH 7.2
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
- 有效期
- 12 months
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: "Extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens." in: PLoS ONE, Vol. 7, Issue 6, pp. e39908, (2012) (PubMed).
: "RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 10, pp. 2976-87, (2006) (PubMed).
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: "Extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens." in: PLoS ONE, Vol. 7, Issue 6, pp. e39908, (2012) (PubMed).
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- 抗原
- CEACAM5/6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5/6 (CEACAM5/6))
- 别名
- cd66c/e (CEACAM5/6 产品)
- 别名
- CEACAM5 antibody, CEA antibody, carcinoembryonic antigen related cell adhesion molecule 5 antibody, carcinoembryonic antigen-related cell adhesion molecule 5 antibody, CEACAM5 antibody
- 背景
- CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM6 expression is strongly upregulated already during early stages of adenocarcinoma formation (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1).
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