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PCDHG 抗体 (C-Term, Cytoplasmic Domain, pan)

PCDHG 适用: 小鼠, 大鼠 ICC, IF, WB 宿主: 小鼠 Monoclonal S159-5 unconjugated
产品编号 ABIN5539938
发货至: 中国
  • 抗原
    PCDHG (Protocadherin gamma Cluster (PCDHG))
    抗原表位
    AA 808-931, C-Term, Cytoplasmic Domain, pan
    适用
    小鼠, 大鼠
    宿主
    小鼠
    克隆类型
    单克隆
    应用范围
    Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
    特异性
    This antibody detects a ~100 kDa protein. Cross-reacts with all Gamma- protocadherin-A, -B and -C proteins. Species: Mouse and Rat.
    纯化方法
    Protein G Chromatography
    免疫原
    Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A-subfamily: amino acids ~807-930, B-subfamily: amino acids ~789-912 and C subfamily).
    克隆位点
    S159-5
    亚型
    IgG1
  • 应用备注
    Western blot: 1/1000, 1 μg/mL was sufficient for detection of PCDHG (pan) in 20 μg of Rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody. Immunocytochemistry .
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS pH 7.4, 50 % Glycerol, 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
  • 抗原
    PCDHG (Protocadherin gamma Cluster (PCDHG))
    别名
    pcdhg
    别名
    protocadherin gamma cluster antibody, Pcdhg@ antibody
    背景
    The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
    基因ID
    93709
    UniProt
    Q91XZ0
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