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- 抗原 See all SET/TAF-I (SET) 抗体
- SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
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抗原表位
- AA 47-75, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SET/TAF-I antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 amino acids from the N-terminal region of human SET.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SET Primary Antibody
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anti-SET Nuclear Oncogene (SET) (N-Term) antibody
Verified SET 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 1-277) antibodySET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 146-277) antibodySET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人, 小鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 1-277) antibodySET 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal M1-F5 unconjugated
anti-SET Nuclear Oncogene (SET) (N-Term) antibodySET 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人, 小鼠, 大鼠 WB, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 147-235) antibodySET 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
- 别名
- SET (SET 产品)
- 别名
- 2PP2A antibody, I2PP2A antibody, IGAAD antibody, IPP2A2 antibody, PHAPII antibody, TAF-I antibody, TAF-IBETA antibody, 2610030F17Rik antibody, 5730420M11Rik antibody, AA407739 antibody, I-2PP2A antibody, StF-IT-1 antibody, 2pp2a antibody, i2pp2a antibody, igaad antibody, ipp2a2 antibody, phapii antibody, set antibody, set-a antibody, set-b antibody, taf-ibeta antibody, wu:fb30g11 antibody, wu:fd16c08 antibody, SET nuclear proto-oncogene antibody, SET nuclear oncogene antibody, SET translocation antibody, SET nuclear proto-oncogene L homeolog antibody, SET nuclear proto-oncogene b antibody, SET antibody, Set antibody, LOC403555 antibody, set.L antibody, setb antibody
- 背景
- Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.
- 分子量
- 33 kDa
- 基因ID
- 6418
- UniProt
- Q01105
- 途径
- Apoptosis
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