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Deoxyuridine Triphosphatase (DUT) (AA 170-198), (C-Term) 抗体

DUT 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5534888
发货至: 中国
  • 抗原 See all Deoxyuridine Triphosphatase (DUT) 抗体
    Deoxyuridine Triphosphatase (DUT)
    抗原表位
    • 15
    • 15
    • 12
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 170-198, C-Term
    适用
    • 83
    • 32
    • 18
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 80
    • 2
    • 1
    克隆类型
    • 82
    • 1
    多克隆
    标记
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    非结合性
    应用范围
    • 66
    • 26
    • 26
    • 26
    • 22
    • 15
    • 8
    • 6
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This DUT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the C-terminal region of human DUT.
    亚型
    Ig Fraction
    Top Product
    Discover our top product DUT Primary Antibody
  • 应用备注
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    Deoxyuridine Triphosphatase (DUT)
    别名
    DUT (DUT 产品)
    物质类
    Viral Protein
    背景
    This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
    分子量
    27 kDa
    基因ID
    1854
    UniProt
    P33316
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