MAD6 antibody, MXD6 antibody, ROX antibody, bHLHd3 antibody, etID309773.22 antibody, fb16b12 antibody, fb55f03 antibody, wu:fb16b12 antibody, wu:fb55f03 antibody, wu:fd06a08 antibody, wu:fz74f10 antibody, Rox antibody, Mnt antibody, zgc:165490 antibody, mnt antibody, rox antibody, MGC98824 antibody, MAX network transcriptional repressor antibody, max interactor 1, dimerization protein antibody, max binding protein antibody, MAX network transcriptional repressor b antibody, MAX network transcriptional repressor L homeolog antibody, MNT antibody, mxi1 antibody, Mnt antibody, mntb antibody, mnt.L antibody
背景
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.