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IL-1 beta 抗体 (N-Term)

Name: IL-1 beta 抗体 (N-Term)
SKU: ABIN5326748
Availability: OutOfStock

IL1B 适用: 人, 小鼠, 兔, 犬, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-IL1B Antibody Titration: 0. (IL-1 beta 抗体 (N-Term))

Sample Type: Human Macrophange CellsGreen: primaryRed: phallodinBlue: DAPIYellow: green/redPrimary Dilution: 1:200Secondary Antibody: anti-Rabbit IgG-FITCSecondary Dilution: 1:1000Image Submitted By: Milan FialaUniversity of California, Los Angeles (IL-1 beta 抗体 (N-Term))

IHC

3 images

(2 references)

产品编号 ABIN5326748

发货至: 中国

Datasheet as PDF

抗原 See all IL-1 beta (IL1B) 抗体

IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
抗原表位
17

15

15

15

8

7

7

7

6

6

5

5

5

5

4

4

4

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
N-Term
适用
131

83

46

26

23

13

8

7

7

7

5

3

3

1

1

1
人, 小鼠, 兔, 犬, 马
宿主
177

67

6

6

4

2

2
兔
Compatible Secondaries
克隆类型
184

78

1
多克隆
标记
137

38

23

9

8

6

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2
This IL-1 beta antibody is un-conjugated
应用范围
182

105

89

48

46

39

28

18

15

15

14

14

13

10

10

7

6

4

3

3

3

3

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

序列

MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL

预测反应

Dog: 92%, Horse: 86%, Human: 100%, Mouse: 75%, Rabbit: 92%

产品特性

This is a rabbit polyclonal antibody against IL1B. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human IL1B

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anti-Interleukin 1, beta (IL1B) (AA 161-269) antibody
IL1B 适用: 人, 小鼠, 大鼠, Cow, 兔 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interleukin 1, beta (IL1B) antibody
IL1B 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3A6 unconjugated

anti-Interleukin 1, beta (IL1B) (AA 170-269) antibody
IL1B 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 2A8 unconjugated

anti-Interleukin 1, beta (IL1B) (AA 117-269) antibody
IL1B 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 6F12D5 unconjugated

anti-Interleukin 1, beta (IL1B) (AA 117-269) antibody
IL1B 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5C3B7 unconjugated

anti-Interleukin 1, beta (IL1B) (AA 1-266) antibody
IL1B 适用: 绵羊 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interleukin 1, beta (IL1B) (AA 1-269) antibody
IL1B 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Interleukin 1, beta (IL1B) antibody
IL1B 适用: 小鼠, 大鼠 WB, ELISA, IHC, IP, FACS, Neut, RIA 宿主: 兔 Polyclonal unconjugated

anti-Interleukin 1, beta (IL1B) (AA 148-174) antibody
IL1B 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21917 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 269 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Lee, Lu, Chai, Sheu, Chen, Huang, Kao, Chen, Chung, Sung, Chang, Lee, Yip: "Circulating microparticles enhanced rat vascular wall remodeling following endothelial denudation." in: American journal of translational research, Vol. 8, Issue 11, pp. 4511-4522, (2016) (PubMed).

Wang, Jiang, Li, He, Zhao, Yang, Zhu, Yin, Li, Wang, Liu, Shang, Yang, Wang, Zhen, Zhang, Yu, Zhong, Ye, Huang, Yuan: "Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." in: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).
抗原

IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

别名

IL1B (IL1B 产品)

别名

IL-1 antibody, IL1-BETA antibody, IL1F2 antibody, IL-1BETA antibody, IL1beta antibody, il1-b antibody, zgc:111873 antibody, IL-1B antibody, IL-1beta antibody, Il-1b antibody, IL1B antibody, IL-1 beta antibody, IL-1b antibody, interleukin 1 beta antibody, interleukin 1, beta antibody, IL1B antibody, il1b antibody, Il1b antibody

背景

IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Alias Symbols: IL-1, IL1-BETA, IL1F2
Protein Interaction Partner: PTPN1, LYN, FYN, CMA1, CASP1, APP, SP1, EGR1, ELAVL1, CASP4, IL1RAP, PRTN3, IL1R2, IL1R1, IL1B, MMP2, ADRB2, A2M, UBE2N, ZNF675, MAPK8IP2,
Protein Size: 269

分子量

17 kDa

基因ID

3553

NCBI登录号

NM_000576, NP_000567

UniProt

P01584

途径

NF-kappaB Signaling, Interferon-gamma Pathway, TLR signaling, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome