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CD19 抗体

CD19 适用: 人 FACS, ICC 宿主: 小鼠 Monoclonal 4G7 unconjugated
产品编号 ABIN509573
发货至: 中国
  • 抗原 See all CD19 抗体
    CD19 (CD19 Molecule (CD19))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CD19 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunocytochemistry (ICC)
    特异性
    The mouse monoclonal antibody 4G7 recognizes an extracellular epitope of human CD19.
    交叉反应 (详细)
    Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Human CCL (chronic lymphocytic leukemia) cells
    克隆位点
    4G7
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CD19 Primary Antibody
  • 应用备注
    Flow cytrometry: Recommended dilution: 1 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Andersen, Pedersen, Woetmann, Villingshøj, Stockhausen, Odum, Poulsen: "EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 122, Issue 2, pp. 342-9, (2007) (PubMed).

    Martino, Tonelli, Montemurro, Franzoni, Marino, Fazzina, Pession: "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)." in: Oncology reports, Vol. 15, Issue 1, pp. 207-11, (2005) (PubMed).

    Köller, Zwölfer, Steiner, Smolen, Scheinecker: "Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients." in: International immunology, Vol. 16, Issue 11, pp. 1595-604, (2004) (PubMed).

    Porcellini, Vallanti, Nozza, Poli, Lazzarin, Tambussi, Siccardi, Grassi: "Improved thymopoietic potential in aviremic HIV infected individuals treated with HAART by intermittent IL-2 administration." in: AIDS, Vol. 17, Issue 11, pp. 1621-30, (2003) (PubMed).

    Basu, Lynne, Ruiz, Aballa, Ferrell, Brackett: "Cytofluorographic identification of activated T-cell subpopulations in the semen of men with spinal cord injuries." in: Journal of andrology, Vol. 23, Issue 4, pp. 551-6, (2002) (PubMed).

    Dubois, Massacrier, Caux: "Selective attraction of naive and memory B cells by dendritic cells." in: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 633-41, (2001) (PubMed).

    Stockmeyer, Dechant, van Egmond, Tutt, Sundarapandiyan, Graziano, Repp, Kalden, Gramatzki, Glennie, van de Winkel, Valerius: "Triggering Fc alpha-receptor I (CD89) recruits neutrophils as effector cells for CD20-directed antibody therapy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 10, pp. 5954-61, (2000) (PubMed).

    Muench, Roncarolo, Namikawa: "Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver." in: Blood, Vol. 89, Issue 4, pp. 1364-75, (1997) (PubMed).

  • 抗原
    CD19 (CD19 Molecule (CD19))
    别名
    CD19 (CD19 产品)
    背景
    CD19 Molecule,CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.,B4, Leu-12, CVID3
    基因ID
    930
    UniProt
    P15391
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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