The clone LB-2 specifically binds with CD54 also known as Intercellular adhesion molecule-1 (ICAM-1), a cell surface antigen expressed by various types of human immune and non-immune cells. CD54 is an 85-110 kDa type I transmembrane glycoprotein that belongs to the Ig supergene family and is a surrogate marker of antigen presenting cell activation. CD54 is expressed mostly on endothelial cells. It also weakly expressed by naive B and T cells and moderately expressed on activated B and T cells as well as monocytes. CD54 is highly expressed on human myeloma cells, Burkitt's lymphoma cells, erythroleukemia cells, and B-lymphoblastoid cells. The CD54 adhesion molecule plays roles in inflammatory and immune responses and neoplasia.
纯化方法
Purified
纯度
>95 %
质量等级
GMP Grade
免疫原
MHC Class II antigen negative human Blymphoblastoid cell line