IL-17RE (Interleukin 17 receptor E) is an orphan receptor of the IL-17 receptor family. The members of this receptor family play a critical role in inflammatory responses and contribute to the pathology of many autoimmune diseases. IL-17RE is a receptor specific to IL-17C preferentially expressed on tissue epithelial cells and regulates early innate immunity to intestinal pathogens by signaling to downstream components of the mitogen activated protein kinase (MAPK) pathway.