DUBA antibody, AA407879 antibody, AI553596 antibody, BB114028 antibody, DXImx46e antibody, Sfc7 antibody, otud5 antibody, si:bz30i22.1 antibody, si:rp71-30i22.1 antibody, zgc:154072 antibody, wu:fi28a06 antibody, zgc:100839 antibody, OTU deubiquitinase 5 antibody, OTU domain containing 5 antibody, OTU deubiquitinase 5a antibody, OTU deubiquitinase 5 S homeolog antibody, OTU deubiquitinase 5 L homeolog antibody, OTU deubiquitinase 5b antibody, OTUD5 antibody, Otud5 antibody, otud5a antibody, otud5.S antibody, otud5.L antibody, otud5b antibody
背景
DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.