UNC5D 抗体 (AA 112-200) (AbBy Fluor® 750)
-
- 抗原 See all UNC5D 抗体
- UNC5D (Unc-5 Homolog D (UNC5D))
-
抗原表位
- AA 112-200
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This UNC5D antibody is conjugated to AbBy Fluor® 750
-
应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human UNC5H4
- 亚型
- IgG
- Top Product
- Discover our top product UNC5D Primary Antibody
-
anti-Unc-5 Homolog D (UNC5D) (AA 31-130) antibody
UNC5D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-Unc-5 Homolog D (UNC5D) (AA 90-212) antibodyUNC5D 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog D (UNC5D) (AA 31-130) antibodyUNC5D 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
-
- 应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
-
- 抗原
- UNC5D (Unc-5 Homolog D (UNC5D))
- 别名
- UNC5D/UNC5H4 (UNC5D 产品)
- 别名
- UNC5D antibody, PRO34692 antibody, Unc5h4 antibody, D930029E11Rik antibody, mKIAA1777 antibody, unc-5 netrin receptor D antibody, unc-5 homolog D (C. elegans) antibody, Unc5d antibody, UNC5D antibody, unc5d antibody
- 背景
-
Synonyms: Netrin receptor UNC5D, Netrin receptor Unc5h4, Protein unc 5 homolog D, Unc 5 homolog 4, Unc 5 homolog D C. elegans, Unc 5 homolog D, UNC 5D, Unc5h4, FLJ16019, KIAA1777.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
-
