电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

Tankyrase 抗体 (AA 1140-1171) (AbBy Fluor® 680)

适用: 人, 小鼠, 大鼠 WB, IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 680
产品编号 ABIN5011345
发货至: 中国
  • 抗原 See all Tankyrase products
    Tankyrase
    抗原表位
    • 14
    • 2
    • 1
    • 1
    AA 1140-1171
    适用
    人, 小鼠, 大鼠
    宿主
    • 17
    • 2
    克隆类型
    • 17
    • 2
    多克隆
    标记
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Tankyrase antibody is conjugated to AbBy Fluor® 680
    应用范围
    • 19
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Tankyrase
    亚型
    IgG
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Tankyrase
    Abstract
    Tankyrase 产品
    别名
    BcDNA:LD22548 antibody, CG17487 antibody, CG4719 antibody, Dm.pARTb antibody, Dmel\\CG4719 antibody, GB12086 antibody, tankyrase antibody, Tnks antibody, LOC413032 antibody, LOC5578003 antibody, CpipJ_CPIJ017909 antibody
    背景

    Synonyms: TIN1, ARTD5, PARPL, TINF1, TNKS1, pART5, PARP5A, PARP-5a, Tankyrase-1, TANK1, ADP-ribosyltransferase diphtheria toxin-like 5, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I, TNKS

    Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.

    基因ID
    8658
    UniProt
    O95271
You are here:
客服