TTBK1 抗体 (C-Term)
Quick Overview for TTBK1 抗体 (C-Term) (ABIN501089)
抗原
See all TTBK1 (Ttbk1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects TTBK1. It is predicted to not cross-react with TTBK2.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Affinity chromatography
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免疫原
- TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.
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亚型
- IgG
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anti-tau Tubulin Kinase 1 (Ttbk1) (AA 230-258), (N-Term) antibody
Ttbk1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24987 unconjugated
anti-tau Tubulin Kinase 1 (Ttbk1) (AA 667-695) antibodyTtbk1 适用: 人 WB 宿主: 兔 Polyclonal RB42064 unconjugated
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TTBK1 (Ttbk1) (tau Tubulin Kinase 1 (Ttbk1))
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别名
- TTBK1
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背景
- Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.Synonyms: BDTK, Brain-derived tau kinase, KIAA1855, Tau-tubulin kinase 1
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基因ID
- 84630
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UniProt
- Q5TCY1
抗原
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