FNBP1L
适用: 人
IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 680
应用备注
ELISA. Western blot: 0.5 - 2 μg/mL. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
缓冲液
PBS containing 0.02 % sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
C1orf39 antibody, TOCA1 antibody, 2610318I01Rik antibody, AW548221 antibody, RGD1305386 antibody, Toca-1 antibody, zgc:100923 antibody, toca1 antibody, toca-1 antibody, MGC132162 antibody, fnbp1l antibody, formin binding protein 1 like antibody, formin binding protein 1-like antibody, formin binding protein 1 like L homeolog antibody, formin binding protein 1 like S homeolog antibody, FNBP1L antibody, Fnbp1l antibody, fnbp1l antibody, fnbp1l.L antibody, fnbp1l.S antibody
背景
Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells, its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.Synonyms: C1orf39, Formin-binding protein 1-like, TOCA1, Transducer of Cdc42-dependent actin assembly protein 1