TMED10 抗体 (Center)
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- 抗原 See all TMED10 抗体
- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
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抗原表位
- Center
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TMED10 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects TMED10 / TMP21 at Center.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- Peptide affinity chromatography
- 免疫原
- TMP21 antibody was raised against a 18 amino acid peptide from near the center of human TMP21.
- 亚型
- IgG
- Top Product
- Discover our top product TMED10 Primary Antibody
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anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 101-200) antibody
TMED10 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (C-Term) antibodyVerified TMED10 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 143-192) antibodyTMED10 适用: 人, 小鼠, 大鼠, 兔, 犬, 马, Cow, 斑马鱼, 豚鼠, Hamster, 猴, Pig, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 100-200) antibodyTMED10 适用: 人, 小鼠, 大鼠, 兔 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (C-Term) antibodyTMED10 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
- 别名
- TMED10 / TMP21 (TMED10 产品)
- 别名
- tmp21 antibody, P24(DELTA) antibody, S31I125 antibody, S31III125 antibody, TMP21 antibody, Tmp-21-I antibody, p23 antibody, 1110014C03Rik antibody, Tmp21 antibody, p24delta1 antibody, fe06g04 antibody, wu:fb98e10 antibody, wu:fe06g04 antibody, zgc:85681 antibody, transmembrane p24 trafficking protein 10 L homeolog antibody, transmembrane p24 trafficking protein 10 antibody, tmed10.L antibody, TMED10 antibody, Tmed10 antibody, tmed10 antibody
- 背景
- TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the γ-secretase but not theεsecretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the γ and ε-sites and can lead to the accumulation of the Aβ cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased γ-secretase activity but not ε-secretase activity, and increased Aβ production, demonstrating that TMP21 can modulate γsecretase activity.Synonyms: 21 kDa transmembrane-trafficking protein, S31I125, Transmembrane emp24 domain-containing protein 10, Transmembrane protein Tmp21
- 基因ID
- 10972
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