Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
交叉反应 (详细)
Species reactivity (tested):Mouse
纯化方法
Ion exchange chromatography
免疫原
TLR11 antibody was raised against a peptide corresponding to 16 amino acids between the middle and carboxy terminus of mouse TLR11 (GenBank accession no NP_991388).
ELISA. Western blot: 0.5 to 2 μg/mL. Imunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
1.0 mg/mL
缓冲液
PBS containing 0.02 % sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR11 is one of three mouse TLRs that lack a human ortholog (6). It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system (7).Synonyms: Gm287, Toll-like receptor 11