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SIGIRR 抗体 (C-Term)

SIGIRR 适用: 人, 小鼠 WB, EIA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN500712
发货至: 中国
  • 抗原 See all SIGIRR 抗体
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    抗原表位
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    C-Term
    适用
    • 21
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠
    宿主
    • 24
    • 4
    • 1
    克隆类型
    • 24
    • 5
    多克隆
    标记
    • 21
    • 6
    • 2
    This SIGIRR antibody is un-conjugated
    应用范围
    • 27
    • 14
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
    特异性
    This antibody detects SIGIRR / TIR8 at C-term.
    交叉反应 (详细)
    Species reactivity (tested):Human, mouse
    纯化方法
    Peptide affinity chromatography
    免疫原
    SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of mouse SIGIRR.
    亚型
    IgG
    Top Product
    Discover our top product SIGIRR Primary Antibody
  • 应用备注
    ELISA. Western blot: 0.5 to 1 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    别名
    SIGIRR / TIR8 (SIGIRR 产品)
    别名
    TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody
    背景
    SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family (3). Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling (4,5). However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion (4).Synonyms: Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, UNQ301/PRO342
    基因ID
    59307
    UniProt
    Q6IA17
    途径
    Toll-Like Receptors Cascades
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