(1 reference)-
- 抗原 See all RNF168 抗体
- RNF168 (Ring Finger Protein 168 (RNF168))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RNF168 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects RNF168.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse
- 纯化方法
- Peptide affinity chromatography
- 免疫原
- RNF168 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human RNF168.
- 亚型
- IgG
- Top Product
- Discover our top product RNF168 Primary Antibody
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anti-Ring Finger Protein 168 (RNF168) (AA 462-571) antibody
RNF168 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 401-450) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠, 豚鼠, 兔, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 1-571) antibodyRNF168 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 1-571) antibodyRNF168 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠, 豚鼠, 兔, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 194-296) antibodyRNF168 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 300-571) antibodyRNF168 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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: "RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair." in: Journal of cell science, Vol. 127, Issue Pt 10, pp. 2238-48, (2014) (PubMed).
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: "RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair." in: Journal of cell science, Vol. 127, Issue Pt 10, pp. 2238-48, (2014) (PubMed).
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- 抗原
- RNF168 (Ring Finger Protein 168 (RNF168))
- 别名
- RNF168 (RNF168 产品)
- 别名
- 3110001H15Rik antibody, hRNF168 antibody, ring finger protein 168 antibody, ring finger protein 168, E3 ubiquitin protein ligase L homeolog antibody, Rnf168 antibody, rnf168.L antibody, RNF168 antibody
- 背景
- RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.Synonyms: E3 ubiquitin-protein ligase RNF168, RING finger protein 168
- 基因ID
- 165918
- NCBI登录号
- NP_689830
- UniProt
- Q8IYW5
- 途径
- Production of Molecular Mediator of Immune Response
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