PEN2 抗体 (N-Term)
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- 抗原 See all PEN2 (PSENEN) 抗体
- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PEN2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects PEN2 at N-term.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- Peptide affinity chromatrography
- 免疫原
- PEN2 antibody was raised against a 13 amino acid peptide from near the amino terminus of human PEN2.
- 亚型
- IgG
- Top Product
- Discover our top product PSENEN Primary Antibody
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anti-Presenilin Enhancer 2 Homolog (PSENEN) (AA 6-80) antibody
PSENEN 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (AA 39-57) antibodyPSENEN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (AA 1-101) antibodyPSENEN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12-G5 unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (AA 1-50) antibodyPSENEN 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, Opossum WB 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (C-Term) antibodyPSENEN 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, 兔, Cow, 斑马鱼, 猴, Pig, Bat, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (AA 20-69) antibodyPSENEN 适用: 人, 小鼠, 犬, 马, 豚鼠, 兔, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (C-Term) antibodyPSENEN 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, 兔, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Enhancer 2 Homolog (PSENEN) (C-Term) antibodyPSENEN 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
- 别名
- PEN2 (PSENEN 产品)
- 别名
- MSTP064 antibody, PEN-2 antibody, PEN2 antibody, Psenen antibody, ACYPI006208 antibody, 1700023M09Rik antibody, Pen-2 antibody, RGD1312037 antibody, CG33198 antibody, Dmel\\CG33198 antibody, anon-AE003800.1 antibody, dPen-2 antibody, psenen antibody, pen-2 antibody, pen2 antibody, zgc:109727 antibody, presenilin enhancer gamma-secretase subunit antibody, presenilin enhancer 2 antibody, presenilin enhancer gamma secretase subunit antibody, Gamma-secretase subunit pen-2 antibody, presenilin enhancer antibody, presenilin enhancer gamma secretase subunit S homeolog antibody, PSENEN antibody, PEN2 antibody, Psenen antibody, pen-2 antibody, psenen.S antibody, psenen antibody
- 背景
- PEN2, in addition to presenilin, nicastrin, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-α-converting enzyme (TACE) and the β-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic A?β amyloid peptide (from the β and γ cleavage site). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer's disease.Synonyms: Gamma-secretase subunit PEN-2, MDS033, PSENEN, Presenilin enhancer protein 2
- 基因ID
- 55851
- NCBI登录号
- NP_758844
- UniProt
- Q9NZ42
- 途径
- Notch Signaling, Neurotrophin Signaling Pathway
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