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PAK2 抗体 (N-Term)

Name: PAK2 抗体 (N-Term)
SKU: ABIN500441
Availability: OutOfStock

PAK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of PAK2 in Jurkat lysate with this product at (A) 0. (PAK2 抗体 (N-Term))

Immunohistochemistry of PAK2 in mouse spleen tissue with this product at 10 μg/ml. (PAK2 抗体 (N-Term))

IHC (p)

2 images

(2 references)

产品编号 ABIN500441

发货至: 中国

Datasheet as PDF

抗原 See all PAK2 抗体

PAK2 (P21-Activated Kinase 2 (PAK2))
抗原表位
13

11

11

8

7

5

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
100

57

55

3

2

1
人, 小鼠, 大鼠
宿主
97

4
兔
Compatible Secondaries
克隆类型
88

13
多克隆
标记
61

6

5

5

5

5

5

5

1

1

1

1
This PAK2 antibody is un-conjugated
应用范围
60

51

27

15

4

4

3

3

2

2

2

2

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

特异性

This antibody detects PAK2 at N-term.

交叉反应（详细）

Species reactivity (tested):Human, mouse, rat

纯化方法

Peptide affinity chromatography

免疫原

14 amino acid peptide from near the amino terminus of human PAK2

亚型

IgG

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anti-P21-Activated Kinase 2 (PAK2) antibody
PAK2 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3B5 unconjugated

anti-P21-Activated Kinase 2 (PAK2) (AA 1-212) antibody
PAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 2 (PAK2) antibody
PAK2 适用: 人 WB, ELISA, IP, FACS 宿主: 兔 Monoclonal 6D12 unconjugated Recombinant Antibody

anti-P21-Activated Kinase 2 (PAK2) (AA 177-419) antibody
PAK2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 2 (PAK2) (AA 192-222) antibody
PAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 2 (PAK2) (pSer20) antibody
PAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 2 (PAK2) (Ser62) antibody
PAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 2 (PAK2) (Ser192) antibody
PAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 2 (PAK2) (pSer197) antibody
PAK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
缓冲液

PBS containing 0.02 % sodium azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Choi, Pease, Chen, Zhang, Phee: "P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells." in: Immunology, Vol. 154, Issue 2, pp. 309-321, (2018) (PubMed).

Phee, Au-Yeung, Pryshchep, OHagan, Fairbairn, Radu, Kosoff, Mollenauer, Cheng, Chernoff, Weiss: "Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation." in: eLife, Vol. 3, pp. e02270, (2015) (PubMed).
抗原

PAK2 (P21-Activated Kinase 2 (PAK2))

别名

PAK2 (PAK2 产品)

别名

PAK65 antibody, PAKgamma antibody, gamma-PAK antibody, 5330420P17Rik antibody, A130002K10Rik antibody, AI836325 antibody, D16Ertd269e antibody, PAK-2 antibody, mKIAA4182 antibody, pak2 antibody, cb422 antibody, kinase antibody, zgc:91798 antibody, wu:fb71h01 antibody, si:dz198m22.1 antibody, pak65 antibody, pakgamma antibody, PAKI antibody, Pak3 antibody, CH73-159L23.1 antibody, wu:fc52b03 antibody, zgc:113857 antibody, p21 (RAC1) activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2a antibody, p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog antibody, p21 protein (Cdc42/Rac)-activated kinase 2b antibody, PAK2 antibody, Pak2 antibody, pak2a antibody, pak2.S antibody, pak2b antibody

背景

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.Synonyms: Gamma-PAK, PAK 2, PAK gamma, PAK-2, PAK65, Serine/threonine-protein kinase PAK 2, p21-activated kinase 2, p58

基因ID

5062

NCBI登录号

NP_002568

UniProt

Q13177

途径

MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha