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- 抗原 See all MADD 抗体
- MADD (MAP-Kinase Activating Death Domain (MADD))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MADD antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects MADD at C-term.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- DEAE purified
- 免疫原
- MADD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human MADD.
- 亚型
- IgG
- Top Product
- Discover our top product MADD Primary Antibody
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anti-MAP-Kinase Activating Death Domain (MADD) (Internal Region) antibody
MADD 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (C-Term) antibodyMADD 适用: 人, 小鼠 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (Internal Region) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (AA 751-800) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western blot: 1: 250 - 1: 500 dilution, 200 to 220 kDa bands should be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- MADD (MAP-Kinase Activating Death Domain (MADD))
- 别名
- MADD (MADD 产品)
- 别名
- MADD antibody, MGC145371 antibody, DENN antibody, IG20 antibody, RAB3GEP antibody, 9630059K23Rik antibody, MAP kinase activating death domain antibody, MAP-kinase activating death domain antibody, MADD antibody, madd antibody, Madd antibody
- 背景
- MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98 % identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94 % overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87 % identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.Synonyms: DENN, IG20, MAP kinase-activating death domain protein, RAB3GEP, Rab3 GDP/GTP exchange factor
- 基因ID
- 8567
- UniProt
- Q8WXG6
- 途径
- Caspase Cascade in Apoptosis
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