CALHM1 抗体 (AA 161-260) (AbBy Fluor® 750)
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- 抗原 See all CALHM1 抗体
- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
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抗原表位
- AA 161-260
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CALHM1 antibody is conjugated to AbBy Fluor® 750
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human CALHM1/FAM26C
- 亚型
- IgG
- Top Product
- Discover our top product CALHM1 Primary Antibody
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
- 别名
- CALHM1/FAM26C (CALHM1 产品)
- 别名
- FAM26C antibody, Fam26c antibody, RGD1564891 antibody, EG546729 antibody, calcium homeostasis modulator 1 antibody, novel protein similar to vertebrate calcium homeostasis modulator protein family antibody, CALHM1 antibody, LOC557535 antibody, Calhm1 antibody
- 背景
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Synonyms: CAHM1_HUMAN, Calcium homeostasis modulator 1, Calcium homeostasis modulator protein 1, CALHM1, FAM26C, Family with sequence similarity 26, member C, MGC39514, MGC39617, Protein FAM26C.
Background: CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.
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