C-IAP antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1 c-IAP antibody detects both c-IAP1 and c-IAP2.
纯化方法
Affinity chromatography purified via peptide column
ELISA. Western Blot: cIAP antibody can be used for the detection of c-IAP at 1 to 2 μg/mL. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
缓冲液
PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspasesSynonyms: API1, Baculoviral IAP repeat-containing protein 2, C-IAP1, HIAP-2, HIAP2, IAP homolog B, Inhibitor of apoptosis protein 2, MIHB, RING finger protein 48, RNF48, TNFR2-TRAF-signaling complex protein 2, cIAP1