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Carabin 抗体 (N-Term)

TBC1D10C 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499531
发货至: 中国
  • 抗原 See all Carabin (TBC1D10C) 抗体
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    抗原表位
    • 4
    • 2
    • 1
    • 1
    • 1
    N-Term
    适用
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠
    宿主
    • 8
    • 1
    克隆类型
    • 9
    多克隆
    标记
    • 9
    This Carabin antibody is un-conjugated
    应用范围
    • 9
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to Carabin.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Carabin antibody was raised against a 17 amino acid peptide from near the amino terminus of human Carabin.
    亚型
    IgG
    Top Product
    Discover our top product TBC1D10C Primary Antibody
  • 应用备注
    ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    别名
    Carabin (TBC1D10C 产品)
    别名
    CARABIN antibody, EPI64C antibody, 1810062O14Rik antibody, AI428527 antibody, RGD1311490 antibody, TBC1 domain family member 10C antibody, TBC1 domain family, member 10c antibody, TBC1 domain family, member 10C antibody, TBC1D10C antibody, Tbc1d10c antibody
    背景
    Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
    基因ID
    374403
    NCBI登录号
    NP_940919
    UniProt
    Q8IV04
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