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BACE2 抗体 (N-Term)

BACE2 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499395
发货至: 中国
  • 抗原 See all BACE2 抗体
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    抗原表位
    • 15
    • 8
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    • 3
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    • 2
    • 2
    • 2
    • 1
    • 1
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    N-Term
    适用
    • 43
    • 32
    • 11
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 62
    • 2
    • 1
    克隆类型
    • 64
    • 1
    多克隆
    标记
    • 29
    • 10
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This BACE2 antibody is un-conjugated
    应用范围
    • 46
    • 31
    • 20
    • 13
    • 13
    • 11
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    BACE2 antibody was raised against a synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Human BACE2 (N-Terminus) Peptide
    亚型
    IgG
    Top Product
    Discover our top product BACE2 Primary Antibody
  • 应用备注
    ELISA. Western Blot: BACE2 can be used for detection of BACE2 at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    别名
    BACE2 (BACE2 产品)
    别名
    AEPLC antibody, ALP56 antibody, ASP1 antibody, ASP21 antibody, BAE2 antibody, CEAP1 antibody, DRAP antibody, 1110059C24Rik antibody, AI850424 antibody, ARP1 antibody, CDA13 antibody, beta-site APP-cleaving enzyme 2 antibody, BACE2 antibody, Bace2 antibody
    背景
    Accumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1
    基因ID
    25825
    UniProt
    Q9Y5Z0
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