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AES 抗体 (C-Term, N-Term)

Name: AES 抗体 (C-Term, N-Term)
SKU: ABIN499225
Availability: OutOfStock

AES 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of AES in 293 cell lysate with AES antibody at (A) 1, (B) 2 and (C) 4 μg/ml. (AES 抗体 (C-Term, N-Term))

Immunocytochemistry of AES in HeLa cells with AES antibody at 10 μg/ml. (AES 抗体 (C-Term, N-Term))

Immunofluorescence of AES in Hela cells with AES antibody at 20 µg/ml (AES 抗体 (C-Term, N-Term))

3 images

产品编号 ABIN499225

发货至: 中国

Datasheet as PDF

抗原 See all AES 抗体

AES (Amino-terminal Enhancer of Split (AES))
抗原表位
15

11

8

6

5

4

2

1

1

1
C-Term, N-Term
适用
55

15

14

7

5

5

3

3

3

1
人, 小鼠, 大鼠
宿主
52

2

1
兔
Compatible Secondaries
克隆类型
54

1
多克隆
标记
25

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This AES antibody is un-conjugated
应用范围
31

22

13

13

5

4

4

4

3

1

1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

特异性

AES antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human AES.

纯化方法

Affinity chromatography purified via peptide column

免疫原

Human AES / Amino-terminal enhancer of split / GRG / ESP1 / TLE5 (C-Terminus) Peptide

亚型

IgG

Top Product

Discover our top product AES Primary Antibody
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264), (N-Term) antibody
AES 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibody
AES 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibody
Verified AES 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibody
AES 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibody
AES 适用: 人 IP 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibody
AES 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibody
AES 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (AA 143-192) antibody
AES 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 非洲爪蟾, 斑马鱼, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibody
AES 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibody
AES 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA. Western Blot: AES antibody can be used for the detection of AES at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
缓冲液

PBS containing 0.02 % Sodium Azide as preservative

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原

AES (Amino-terminal Enhancer of Split (AES))

别名

AES / ESP1 (AES 产品)

别名

AES-1 antibody, AES-2 antibody, ESP1 antibody, GRG antibody, GRG5 antibody, TLE5 antibody, AL024115 antibody, Esp1 antibody, Grg antibody, Grg-5 antibody, Grg5 antibody, Tle5 antibody, zgc:64216 antibody, aes-1 antibody, aes-2 antibody, esp1 antibody, grg antibody, grg5 antibody, tle5 antibody, xgrg-5 antibody, AES antibody, amino-terminal enhancer of split antibody, amino-terminal enhancer of split S homeolog antibody, AES antibody, Aes antibody, aes antibody, aes.S antibody

背景

Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (2,3). AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis (4). It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. (4). Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (4).Synonyms: AES1, Amino-terminal enhancer of split, GRG protein, Gp130-associated protein GAM

基因ID

166

NCBI登录号

NP_001121

UniProt

Q08117

途径

WNT signaling, SARS-CoV-2 Protein Interactome