Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
CAM2 antibody, CAMK2 antibody, CAMKB antibody, Camk2d antibody, Ck2b antibody, camk2 antibody, camk2b antibody, cam2 antibody, camkb antibody, CAMK2B antibody, calcium/calmodulin dependent protein kinase II beta antibody, calcium/calmodulin-dependent protein kinase II, beta antibody, calcium/calmodulin-dependent protein kinase II beta antibody, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog antibody, calcium/calmodulin dependent protein kinase (CaM kinase) II beta L homeolog antibody, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta antibody, CAMK2B antibody, Camk2b antibody, camk2a.S antibody, camk2b.L antibody
背景
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40-fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.Synonyms: CAM2, CAMKB, CAMKIIb, CaM kinase II subunit beta, CaM-kinase II beta chain, CaMK-II subunit beta, Calcium/calmodulin-dependent protein kinase type II beta chain