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SUV39H1 抗体 (N-Term)

SUV39H1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3029052
发货至: 中国
  • 抗原 See all SUV39H1 抗体
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    抗原表位
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    N-Term
    适用
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    • 17
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    人, 小鼠
    宿主
    • 59
    • 8
    克隆类型
    • 59
    • 8
    多克隆
    标记
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    • 7
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    This SUV39H1 antibody is un-conjugated
    应用范围
    • 39
    • 34
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    • 6
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    Western Blotting (WB), ELISA
    纯化方法
    Purified
    免疫原
    N-terminal purified recombinant protein was used as the immunogen for the SUV39H1 antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product SUV39H1 Primary Antibody
  • 应用备注
    Titration of the SUV39H1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the SUV39H1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    别名
    SUV39H1 (SUV39H1 产品)
    别名
    H3-K9-HMTase 1 antibody, KMT1A antibody, MG44 antibody, SUV39H antibody, AI852103 antibody, AL022883 antibody, DXHXS7466e antibody, mIS6 antibody, RGD1565028 antibody, kmt1a antibody, suv39h antibody, fe02c04 antibody, suv39h1 antibody, wu:fe02c04 antibody, zgc:101027 antibody, fe47h06 antibody, wu:fb18a10 antibody, wu:fe47h06 antibody, zgc:136593 antibody, suppressor of variegation 3-9 homolog 1 antibody, suppressor of variegation 3-9 homolog 1 (Drosophila) antibody, suppressor of variegation 3-9 homolog 1 L homeolog antibody, suppressor of variegation 3-9 homolog 1a antibody, suppressor of variegation 3-9 homolog 1b antibody, SUV39H1 antibody, Suv39h1 antibody, suv39h1.L antibody, suv39h1a antibody, suv39h1b antibody
    背景
    Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
    UniProt
    O43463
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