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PTEN 抗体 (AA 69-104)

Name: PTEN 抗体 (AA 69-104)
SKU: ABIN3032214
Availability: OutOfStock

PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of PTEN antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PTEN gene (2). (PTEN 抗体 (AA 69-104))

Confocal immunofluorescent analysis of PTEN antibody with MCF-7 cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (PTEN 抗体 (AA 69-104))

IHC analysis of FFPE human lung carcinoma tissue stained with PTEN antibody (PTEN 抗体 (AA 69-104))

IHC

PTEN antibody western blot analysis in HL-60 lysate (PTEN 抗体 (AA 69-104))

IHC

7 images

产品编号 ABIN3032214

发货至: 中国

Datasheet as PDF

抗原 See all PTEN 抗体

PTEN (Phosphatase and Tensin Homolog (PTEN))
抗原表位
18

17

16

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 69-104
适用
46

17

17
人
宿主
45

1
兔
Compatible Secondaries
克隆类型
45

1
多克隆
标记
31

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This PTEN antibody is un-conjugated
应用范围
25

21

14

14

13

13

5

5

3

2
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

纯化方法

Purified

免疫原

A portion of amino acids 69-104 from the human protein was used as the immunogen for this PTEN antibody.

亚型

Ig Fraction

Top Product

Discover our top product PTEN Primary Antibody
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibody
PTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibody
PTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pTyr315) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB30516 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pTyr176) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39742 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pThr383) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39429 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 361-390) antibody
PTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39430 unconjugated

应用备注

Titration of the PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

限制

仅限研究用
状态

Liquid

缓冲液

In 1X PBS pH 7.4 with 0.09 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
抗原

PTEN (Phosphatase and Tensin Homolog (PTEN))

别名

PTEN (PTEN 产品)

别名

10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, MMAC1 antibody, PTEN1 antibody, TEP1 antibody, 2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, Mmac antibody, PTENP1 antibody, wu:fc52g04 antibody, zgc:73086 antibody, fa11a08 antibody, fb73f10 antibody, fc83f12 antibody, fd16b10 antibody, fk90e11 antibody, pten antibody, si:bz1g13.4 antibody, wu:fa11a08 antibody, wu:fb73f10 antibody, wu:fc83f12 antibody, wu:fd16b10 antibody, wu:fk90e11 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, phosphatase and tensin homolog A antibody, phosphatase and tensin homolog B antibody, PTEN antibody, Pten antibody, pten.L antibody, ptena antibody, ptenb antibody

背景

PTEN, (phosphatase and tensin homolog deleted on chromosome 10), also known as MMAC1 (mutated in multiple advanced cancers 1), is a tumor suppressor implicated in a large number of human tumors. The PTEN phosphatase incorporates the catalytic motif (HCXXGXXRS/T) that is a signature of the protein tyrosine phosphatase family. Recombinant human PTEN is a dual phosphatase with ability to dephosphorylate both tyrosine and serine/threonine residues. PTEN functions primarily as a lipid phosphatase to regulate signal transduction pathways, with a primary target identified as phosphatidylinositol 3,4,5 trisphosphate. In addition, PTEN presents weak tyrosine phosphatase activity, which may downregulate signaling pathways involving focal adhesion kinase or Shc. PTEN negatively regulates activation of the serine/threonine kinase Akt/PKB by blocking its phosphorylation, thereby inhibiting the PI 3 kinase Akt signaling pathway, which is important for cell survival. In vivo, the majority of PTEN missense mutations detected in tumor specimens target the phosphatase domain and cause a loss in PTEN phosphatase activity. Mutations in PTEN are associated with several common cancers including prostate, brain and breast cancer, and with Cowden's disease, an autosomal dominant disorder conferring susceptibility to benign and malignant tumors. Germline mutations of PTEN are also linked Lhermitte-Duclos disease and Bannayan-Zonana syndrome. Mutations of PTEN occur in 60 to 80 % of prostate cancers. PTEN is also essential for embryonic development.

UniProt

P60484

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling