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PROX1 抗体 (AA 185-214)

This anti-PROX1 antibody is a 兔 多克隆 antibody detecting PROX1 in WB, ELISA 和 IHC. Suitable for 人.
产品编号 ABIN3032343
发货至: 中国

Quick Overview for PROX1 抗体 (AA 185-214) (ABIN3032343)

抗原

See all PROX1 抗体
PROX1 (Prospero Homeobox 1 (PROX1))

适用

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宿主

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克隆类型

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多克隆

标记

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This PROX1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    AA 185-214

    交叉反应 (详细)

    Expected species reactivity: Mouse

    纯化方法

    Antigen affinity purified

    免疫原

    A portion of amino acids 185-214 from the human protein was used as the immunogen for this PROX1 antibody.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the PROX1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    PROX1 (Prospero Homeobox 1 (PROX1))

    别名

    PROX1

    背景

    The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.

    UniProt

    Q92786

    途径

    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
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