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PTEN 抗体 (pThr382)
PTEN
适用: 人
DB, ELISA
宿主: 兔
Polyclonal
unconjugated
PTEN抗体详情
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抗原
See all PTEN 抗体
PTEN
(Phosphatase and Tensin Homolog (PTEN))
抗原表位
All epitopes for PTEN 抗体
pThr382
适用
All reactivities for PTEN 抗体
人
宿主
All hosts for PTEN 抗体
兔
克隆类型
All clonalities for PTEN 抗体
多克隆
标记
All conjugates for PTEN 抗体
This PTEN antibody is un-conjugated
应用范围
All applications for PTEN 抗体
Dot Blot (DB), ELISA
交叉反应 (详细)
Expected species reactivity: Mouse, Xenopus
纯化方法
Antigen affinity purified
免疫原
This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT382 of human PTEN.
亚型
Ig Fraction
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Discover our top product PTEN Primary Antibody
Alternatives
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anti-Phosphatase and Tensin Homolog (PTEN) (C-Term), (pSer380), (pThr382), (pThr383) antibody
PTEN
适用: 人, 小鼠, 大鼠, 犬, 斑马鱼
WB, IHC, IF, IP, IC
宿主: 兔
Polyclonal
unconjugated
使用细节
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应用备注
Titration of the phospho-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
限制
仅限研究用
贮存及处理
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状态
Liquid
缓冲液
In 1X PBS pH 7.4 with 0.09 % sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
PTEN目标详情
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抗原
PTEN
(Phosphatase and Tensin Homolog (PTEN))
别名
PTEN (PTEN 产品 )
别名
10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, MMAC1 antibody, PTEN1 antibody, TEP1 antibody, 2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, Mmac antibody, PTENP1 antibody, wu:fc52g04 antibody, zgc:73086 antibody, fa11a08 antibody, fb73f10 antibody, fc83f12 antibody, fd16b10 antibody, fk90e11 antibody, pten antibody, si:bz1g13.4 antibody, wu:fa11a08 antibody, wu:fb73f10 antibody, wu:fc83f12 antibody, wu:fd16b10 antibody, wu:fk90e11 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, phosphatase and tensin homolog A antibody, phosphatase and tensin homolog B antibody, PTEN antibody, Pten antibody, pten.L antibody, ptena antibody, ptenb antibody
背景
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
UniProt
P60484
途径
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Inositol Metabolic Process , Synaptic Membrane , Regulation of Cell Size , Autophagy , Platelet-derived growth Factor Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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