MARK1 抗体 (AA 6-40)
Quick Overview for MARK1 抗体 (AA 6-40) (ABIN3031687)
抗原
See all MARK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-40
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纯化方法
- Purified
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免疫原
- A portion of amino acids 6-40 from the human protein was used as the immunogen for this MARK1 antibody.
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亚型
- Ig Fraction
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anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 560-700) antibody
MARK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (Internal Region) antibodyMARK1 适用: 人, 猴, 兔, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (N-Term) antibodyMARK1 适用: 人, 猴, 兔, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (N-Term) antibodyMARK1 适用: 人, 猴, 兔, Bat, Cow, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 6-40), (N-Term) antibodyMARK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB8545 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (Center) antibodyMARK1 适用: 人, 小鼠, 大鼠, 斑马鱼 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) antibodyMARK1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) antibodyMARK1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 643-674), (C-Term) antibodyMARK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1272 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 671-700), (C-Term) antibodyMARK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB8547 unconjugated
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应用备注
- Titration of the MARK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MARK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
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别名
- MARK1
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背景
- MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
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UniProt
- Q9P0L2
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途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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