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LIN28A 抗体 (AA 108-138)

LIN28A 适用: 人, 小鼠 WB, ELISA, IF, IHC, FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3031626
发货至: 中国
  • 抗原 See all LIN28A 抗体
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    抗原表位
    • 15
    • 9
    • 9
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 108-138
    适用
    • 101
    • 34
    • 27
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 85
    • 18
    克隆类型
    • 80
    • 23
    多克隆
    标记
    • 46
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIN28A antibody is un-conjugated
    应用范围
    • 62
    • 36
    • 23
    • 17
    • 16
    • 14
    • 14
    • 13
    • 9
    • 7
    • 6
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)
    纯化方法
    Purified
    免疫原
    A portion of amino acids 108-138 from the human protein was used as the immunogen for this LIN28A antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product LIN28A Primary Antibody
  • 应用备注
    Titration of the LIN28A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:100,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the LIN28A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    别名
    LIN28A (LIN28A 产品)
    别名
    CSDD1 antibody, LIN-28 antibody, LIN28 antibody, ZCCHC1 antibody, lin-28A antibody, AL024421 antibody, ENSMUSG00000070700 antibody, Gm10299 antibody, Lin-28 antibody, Lin28 antibody, Tex17 antibody, csdd1 antibody, lin-28 antibody, lin28 antibody, zcchc1 antibody, sb:cb650 antibody, zgc:55584 antibody, RGD1566408 antibody, lin-28 homolog A antibody, lin-28 homolog A (C. elegans) antibody, lin-28 homolog A S homeolog antibody, LIN28A antibody, Lin28a antibody, lin28a.S antibody, lin28a antibody
    背景
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
    UniProt
    Q9H9Z2
    途径
    Stem Cell Maintenance
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