Integrin beta 7 抗体 (AA 737-765)
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- 抗原 See all Integrin beta 7 (ITGB7) 抗体
- Integrin beta 7 (ITGB7)
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抗原表位
- AA 737-765
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Integrin beta 7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Antigen affinity purified
- 免疫原
- A portion of amino acids 737-765 from the human protein was used as the immunogen for this Integrin beta 7 antibody.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product ITGB7 Primary Antibody
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- 应用备注
- Titration of the Integrin beta 7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Aliquot the Integrin beta 7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- 抗原
- Integrin beta 7 (ITGB7)
- 别名
- Integrin beta 7 (ITGB7 产品)
- 别名
- Ly69 antibody, integrin beta 7 antibody, integrin subunit beta 7 antibody, integrin, beta 7 antibody, Itgb7 antibody, ITGB7 antibody
- 背景
- Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
- UniProt
- P26010
- 途径
- Integrin Complex
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