IgD 抗体 (AA 37-64)
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- 抗原 See all IgD 抗体
- IgD
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抗原表位
- AA 37-64
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IgD antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Purified
- 免疫原
- A portion of amino acids 37-64 from the human protein was used as the immunogen for this IGHD antibody.
- 克隆位点
- 607CT8-4-4
- 亚型
- IgM
- Top Product
- Discover our top product IgD Primary Antibody
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- 应用备注
- Titration of the IGHD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Aliquot the IGHD antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- 抗原
- IgD
- 别名
- IGHD (IgD 产品)
- 别名
- IgD antibody, Igh-5 antibody, immunoglobulin heavy constant delta antibody, immunoglobulin delta heavy chain constant region antibody, Ighd antibody, Igd antibody, IGHD antibody
- 物质类
- Antibody
- 背景
- IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
- UniProt
- P01880
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