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IGF1R 抗体 (AA 51-77)

Name: IGF1R 抗体 (AA 51-77)
SKU: ABIN3031345
Availability: OutOfStock

IGF1R 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

Western blot analysis of IGF1R antibody and WiDr lysate. (IGF1R 抗体 (AA 51-77))

Confocal immunofluorescent analysis of IGF1R antibody with WiDr cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (IGF1R 抗体 (AA 51-77))

IGF1R antibody IHC analysis in formalin fixed and paraffin embedded brain tissue. (IGF1R 抗体 (AA 51-77))

IHC

IGF1R antibody flow cytometric analysis of WiDr cells (green) compared to a negative control (blue). (IGF1R 抗体 (AA 51-77))

FACS

6 images

产品编号 ABIN3031345

发货至: 中国

Datasheet as PDF

抗原 See all IGF1R 抗体

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
抗原表位
26

23

22

14

12

12

12

10

7

6

6

5

5

5

5

5

4

4

4

4

4

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 51-77
适用
195

119

102

16

8

8

7

3

3

2

2

2

1

1

1
人
宿主
182

27

2

1
兔
Compatible Secondaries
克隆类型
186

26
多克隆
标记
126

9

8

7

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3

2
This IGF1R antibody is un-conjugated
应用范围
132

73

61

57

32

25

17

13

13

11

5

4

4

3

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

交叉反应（详细）

Expected species reactivity: Mouse, Rat

纯化方法

Purified

免疫原

A portion of amino acids 51-77 from the human protein was used as the immunogen for this IGF1R antibody.

亚型

Ig Fraction

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anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1161) antibody
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anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1165), (pTyr1166) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1335-1366), (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01458 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 660-760) antibody
IGF1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1101-1367) antibody
IGF1R 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 3G5C1 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr980) antibody
IGF1R 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (Tyr1346) antibody
IGF1R 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Titration of the IGF1R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50

限制

仅限研究用
状态

Liquid

缓冲液

In 1X PBS, pH 7.4, with 0.09 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Aliquot the IGF1R antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
抗原

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

别名

IGF1R (IGF1R 产品)

别名

CMT2N antibody, CD221 antibody, IGFIR antibody, IGFR antibody, JTK13 antibody, IGFIRC antibody, IGFR1 antibody, IGF-1R antibody, IGF1R antibody, DKFZp469I0618 antibody, igf-1r antibody, xIGF-1R antibody, xIGFR antibody, xigf1r antibody, A330103N21Rik antibody, D930020L01 antibody, hyft antibody, igf-ir antibody, IGF-IR antibody, IGF-IRb antibody, wu:fb03h06 antibody, IGF-IRa antibody, sb:eu1090 antibody, wu:fi20b10 antibody, alanyl-tRNA synthetase antibody, insulin like growth factor 1 receptor antibody, insulin-like growth factor 1 receptor antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I receptor antibody, insulin like growth factor 1 receptor S homeolog antibody, insulin-like growth factor 1b receptor antibody, insulin-like growth factor 1a receptor antibody, AARS antibody, IGF1R antibody, Igf1r antibody, igf1r antibody, Igf1 antibody, LOC780503 antibody, LOC100136427 antibody, igf1r.S antibody, igf1rb antibody, igf1ra antibody

背景

IGF1R is a tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1 receptor is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.

UniProt

P08069

途径

RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy