EED 抗体 (AA 269-303)
Quick Overview for EED 抗体 (AA 269-303) (ABIN3030801)
抗原
See all EED 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 269-303
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纯化方法
- Antigen affinity purified
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免疫原
- This EED antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 269-303 amino acids from the central region of mouse Eed.
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亚型
- Ig Fraction
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anti-Embryonic Ectoderm Development (EED) (N-Term) antibody
EED 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 1-100) antibodyEED 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 342-441) antibodyEED 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 142-441) antibodyEED 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 1-300) antibodyEED 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 269-303) antibodyEED 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB51180 unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 1-441) antibodyEED 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 21-70) antibodyEED 适用: 人, 小鼠, 大鼠, 非洲爪蟾, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔, Bat, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 1-300) antibodyEED 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Embryonic Ectoderm Development (EED) (AA 40-74), (N-Term) antibodyEED 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51500 unconjugated
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应用备注
- Titration of the EED antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the EED antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- EED (Embryonic Ectoderm Development (EED))
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别名
- EED
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背景
- Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
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UniProt
- Q921E6
抗原
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